Publications
Peer-reviewed papers and preprints from the lab.
2026
Universal conditional knockout approach to multiple species, from fish to human induced pluripotent stem cells
Jung-Hwa Choi, Jihoon Moon, Youngchul Oh, Thomas M Klompstra, Yujin Kim, Gayoung Baek, Yejin Kwak, Yeongjun Kim, Sangmin Lee, Sujin Park, Jeongmin Ha, Ohbin Kwon, Young Ki Choi, Jeong Hun Kim, Ji-Hyun Lee, Jeongbin Park, Jong Kyoung Kim, Dong Ho Woo, Ki-Jun Yoon, Bon-Kyoung Koo, Heetak Lee
Nucleic Acids Research · doi:10.1093/nar/gkag480
2025
Exploring the Panax ginseng Meyer soil metagenome to uncover antagonistic bacteria against ginseng root rot disease
Jeong A Han, Jaeyeon Lee, Hee Jung An, Eun Seob Yi, Yeongjun Kim, Bon-Kyoung Koo, Heetak Lee, Eun Yu Kim, Ho-Seok Lee
Journal of Ginseng Research · doi:10.1016/j.jgr.2025.07.002
Epithelial WNT secretion drives niche escape of developing gastric cancer
Jaehun Lee, Soomin Kim, Youngchul Oh, Stephan R. Jahn, Jihoon Kim, Yeongjun Kim, Tim Schmäche, Sang-Min Kim, Isaree Teriyapirom, Thomas Groß, Ohbin Kwon, Jungmin Kim, Somi Kim, Anne-Marlen Ada, Andrea Català-Bordes, Youngwon Cho, Jinho Kim, Amanda Andersson-Rolf, Sebastian R. Merker, Joo Yeon Lim, Ji-Yeon Park, Thomas M. Klompstra, Ki-Jun Yoon, Dae-Sik Lim, Ho-Seok Lee, Jong Kyoung Kim, Eunyoung Choi, James R. Goldenring, Jae-Ho Cheong, Hyunki Kim, Daniel E. Stange, Heetak Lee, Bon-Kyoung Koo, Ji-Hyun Lee
Molecular Cancer · doi:10.1186/S12943-025-02543-Z
Sugar nanocluster adhesive boosts wound healing in diabetic mice
Asila Osman, Young Hoon Song, Muneeb Ullah, Yeongjun Kim, Heetak Lee, Jin-Wook Yoo, Dong Soo Hwang, Jeong Hyun Seo
Carbohydrate Polymer Technologies and Applications · doi:10.1016/J.CARPTA.2025.100933
Targeting the HER2-ELF3-KRAS axis: a novel therapeutic strategy for KRAS<SUP>G13D</SUP> colorectal cancer
Soo-Yeon Hwang, Yoojeong Seo, Seojeong Park, Seul-Ah Kim, Inhye Moon, Yi Liu, Seojeong Kim, Eun Seon Pak, Sehyun Jung, Hyeyoon Kim, Kyung-Hwa Jeon, Seung Hee Seo, Inyoung Sung, Heetak Lee, So-Yeon Park, Younghwa Na, Tae Il Kim, Youngjoo Kwon
Molecular Cancer · doi:10.1186/S12943-025-02343-5
2024
Red2Flpe-SCON: a versatile, multicolor strategy for generating mosaic conditional knockout mice
Szu-Hsien Sam Wu, Somi Kim, Heetak Lee, Ji-Hyun Lee, So-Yeon Park, Réka Bakonyi, Isaree Teriyapirom, Natalia Hallay, Sandra Pilat-Carotta, Hans-Christian Theussl, Jihoon Kim, Joo-Hyeon Lee, Benjamin D. Simons, Jong Kyoung Kim, Gabriele Colozza, Bon-Kyoung Koo
Nature Communications · doi:10.1038/s41467-024-49382-y
Transcriptomic Analysis of Air-Liquid Interface Culture in Human Lung Organoids Reveals Regulators of Epithelial Differentiation
Jieun Kim, Eun-Young Eo, Bokyong Kim, Heetak Lee, Jihoon Kim, Bon-Kyoung Koo, Hyung-Jun Kim, Sukki Cho, Jinho Kim, Young-Jae Cho
Cells · doi:10.3390/CELLS13231991
2023
Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2
Gabriele Colozza, Heetak Lee, Alessandra Merenda, Szu-Hsien Sam Wu, Andrea Català-Bordes, Tomasz W. Radaszkiewicz, Ingrid Jordens, Ji-Hyun Lee, Aileen-Diane Bamford, Fiona Farnhammer, Teck Yew Low, Madelon M. Maurice, Vítězslav Bryja, Jihoon Kim, Bon-Kyoung Koo
Science Advances · doi:10.1126/sciadv.adh9673
Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2
Gabriele Colozza, Heetak Lee, Alessandra Merenda, Szu-Hsien Sam Wu, Andrea Català-Bordes, Tomasz W. Radaszkiewicz, Ingrid Jordens, Ji-Hyun Lee, Aileen-Diane Bamford, Fiona Farnhammer, Teck Yew Low, Madelon M. Maurice, Vítězslav Bryja, Jihoon Kim, Bon-Kyoung Koo
Transcriptomes of the tumor-adjacent normal tissues are more informative than tumors in predicting recurrence in colorectal cancer patients
Jinho Kim, Hyunjung Kim, Min-Seok Lee, Heetak Lee, Yeon Jeong Kim, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Hye Kyung Hong, Sridhar Hannenhalli, Yong Beom Cho, Donghyun Park, Sun Shim Choi
Journal of Translational Medicine · doi:10.1186/S12967-023-04053-2
2022
An evolution-based machine learning to identify cancer type-specific driver mutations
Donghyo Kim, Doyeon Ha, Kwanghwan Lee, Heetak Lee, Inhae Kim, Sanguk Kim
Briefings in Bioinformatics · doi:10.1093/BIB/BBAC593
SCON-a Short Conditional intrON for conditional knockout with one-step zygote injection
Szu-Hsien Sam Wu, Heetak Lee, Réka Szép-Bakonyi, Gabriele Colozza, Ayse Boese, Krista R. Gert, Natalia Hallay, Ji-Hyun Lee, Jihoon Kim, Yi Zhu, Margot M. Linssen, Sandra Pilat-Carotta, Peter Hohenstein, Hans-Christian Theussl, Andrea Pauli, Bon-Kyoung Koo
Experimental & Molecular Medicine · doi:10.1038/S12276-022-00891-0
p57<SUP>Kip2</SUP> imposes the reserve stem cell state of gastric chief cells
Ji-Hyun Lee, Somi Kim, Seungmin Han, Jimin Min, Brianna Caldwell, Aileen-Diane Bamford, Andreia Sofia Batista Rocha, JinYoung Park, Sieun Lee, Szu-Hsien Sam Wu, Heetak Lee, Juergen Fink, Sandra Pilat-Carotta, Jihoon Kim, Manon Josserand, Réka Szep-Bakonyi, Yohan An, Young Seok Ju, Anna Philpott, Benjamin D. Simons, Daniel E. Stange, Eunyoung Choi, Bon-Kyoung Koo, Jong Kyoung Kim
Cell Stem Cell · doi:10.1016/J.STEM.2022.04.001
2021
SCON - A Short Conditional intrON for conditional knockout with one-step zygote injection
Szu-Hsien Sam Wu, Réka Szép-Bakonyi, Heetak Lee, Gabriele Colozza, Ayse Boese, Krista Rene Gert, Natalia Hallay, Jihoon Kim, Yi Zhu, Sandra Pilat-Carotta, Hans-Christian Theussl, Andrea Pauli, Bon-Kyoung Koo
2020
Network-based machine learning in colorectal and bladder organoid models predicts anti-cancer drug efficacy in patients
JungHo Kong, Heetak Lee, Donghyo Kim, Seong Kyu Han, Doyeon Ha, Kunyoo Shin, Sanguk Kim
Nature Communications · doi:10.1038/s41467-020-19313-8
Domain-mediated interactions for protein subfamily identification
Heetak Lee, Inhae Kim, Seong Kyu Han, Donghyo Kim, Jungho Kong, Sanguk Kim
Scientific Reports · doi:10.1038/s41598-019-57187-z
2019
Link clustering explains non-central and contextually essential genes in protein interaction networks
Inhae Kim, Heetak Lee, Kwanghwan Lee, Seong Kyu Han, Donghyo Kim, Sanguk Kim
Scientific Reports · doi:10.1038/S41598-019-48273-3
2018
Divergence of Noncoding Regulatory Elements Explains Gene-Phenotype Differences between Human and Mouse Orthologous Genes
Seong Kyu Han, Donghyo Kim, Heetak Lee, Inhae Kim, Sanguk Kim
Molecular Biology and Evolution · doi:10.1093/MOLBEV/MSY056
2017
Energy metabolism and whole-exome sequencing based analysis of Sasang constitution: a pilot study
Hyoung Kyu Kim, Heetak Lee, Ji Ho So, Seung Hun Jeong, Dae Yun Seo, Jong-Yeol Kim, Sanguk Kim, Jin Han
Integrative Medicine Research · doi:10.1016/J.IMR.2017.03.002
2016
OASIS 2: Online application for survival analysis 2 with features for the analysis of maximal lifespan and healthspan in aging research
Seong Kyu Han, Dongyeop Lee, Heetak Lee, Donghyo Kim, Heehwa G. Son, Jae-Seong Yang, Seung-Jae V. Lee, Sanguk Kim
Oncotarget · doi:10.18632/oncotarget.11269
2014
Linear Motif-Mediated Interactions Have Contributed to the Evolution of Modularity in Complex Protein Interaction Networks
Inhae Kim, Heetak Lee, Seong Kyu Han, Sanguk Kim
PLoS Computational Biology · doi:10.1371/journal.pcbi.1003881